13 , 15 Although the magnitude of this effect in clinical settings remains unclear, there is a biological rationale to consider an elevated risk of volume-related symptoms in susceptible individuals, such as older adults, those with orthostatic hypotension, or patients on multidrug antihypertensive regimens
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Uyanikgil et al., 2017) and reduces the expression levels of the proinflammatory cytokines TNF, IL1, IL6 in peripheral nerves (Snchez-Lpez et al., 2018)
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