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The side effect or risk of Semaglutide and Tirzepatide are: weight loss, fatigue, injection site redness or pain, nausea, vomiting, diarrhea, gallbladder flareups, thyroid cancers were a theoretical risk when the class of medication was made 14 years ago or more as it was seen in rats

10.1016/j.cell.2012.03.042 11 DongC.FengW.XuW.YuL.XiangH.ChenY.et al (2020)

Increasing GLP-1 in the postprandial period correlates with the increase in blood flow in brain areas related to satiety, such as the hypothalamus and areas of the prefrontal cortex [53]