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In Alzheimer's disease (AD), the disruption of MAMs enhances inflammatory signaling and impairs the cellular response to ER stress ( 5.4 Mitochondrial dysfunction as an upstream driver of amyloid and tau pathology A significant shift in Alzheimer's disease (AD) research is represented by the Mitochondrial Cascade Hypothesis, which posits that mitochondrial dysfunction is the primary driver of AD pathophysiology, rather than a secondary consequence of Tau or A accumulation ( Importantly, this theory posits that the production of A is influenced by mitochondrial dysfunction triggered by toxins
It also gained a world-famous brand ambassador in Ronaldinho Gacho, one of the most talented players to come out of the soccer-infatuated nation
Superficial confirmed BCC can be treated with imiquimod (subsidised under Special Authority criteria) when standard treatment options, including surgical excision, are contraindicated or inappropriate (Table 2)
Joseph JP and Rajappan K
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