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Some researchers report worse nausea during the luteal phase (the two weeks before menstruation), when progesterone is already causing gastrointestinal symptoms

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It has been reported that the levels of apoptosis markers exhibit a significant negative correlation with sperm capacity for oocyte penetration, Elevated concentrations of apoptotic markers are consistently associated with with impaired sperm-oocyte binding [42]

Animal models further support these findings

TEAEs were reported in 75.7% of participants receiving semaglutide and 55.3% receiving placebo (ESM Table 2)