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This effect was then shown to be mimicked by GLP-1 that acted on the same receptor (94)

A new 2025 real-world cohort study found that people using GLP-1 receptor agonists had a **31% lower risk of developing osteoporosis** compared to non-users (*HR 0.69

These estimates are based on individuals younger than 60

The peptide also enhances glycosaminoglycan synthesis, particularly dermatan sulfate and hyaluronic acid, which provide hydration, compression resistance, and growth factor sequestration functions within dermal matrices

Metformin alleviates renal injury in diabetic rats by inducing Sirt1/FoxO1 autophagic signal axis