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Beyond sleep, DSIP research has revealed potential applications in pain management (showing analgesic effects when administered intracerebroventricularly), addiction treatment (alleviating withdrawal symptoms in 97% of opiate-dependent and 87% of alcohol-dependent patients in one trial), antioxidant defense, and even stroke recovery

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Early concerns about lean mass loss with GLP-1 receptor agonists and the limitations of clinical trial data [3:45]

17, 66 Mice deleted of claudin-1 protein expression die premature owing to dehydration, suggesting a key function for this protein in regulating dermal barrier function