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We recommend GLP-1 medications for individuals who have a significant amount of weight to lose or those with weight-related health concerns

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For most patients, the GI effects are more manageable than cardiovascular stress, but individual tolerance varies

Based on preclinical studies, a systematic review of the neuroprotective mechanisms of GLP-1RA-based therapy in ischemic stroke [67] has shown that administration of drugs of this family before, during, or after an experimental stroke in animals with and without diabetes modulates an acute inflammatory response secondary to brain ischemia, reducing inflammation, endothelial dysfunction and excitotoxicity, as well as decreasing oxidative stress and apoptosis

Bradycardia-induced heart failure with preserved ejection fraction successfully treated with empagliflozin and theophylline: a case report