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In addition, a high-fat diet can significantly increase the level of caspase-3 and decrease the level of bcl-2, which increases the susceptibility of cells to apoptosis and causes a series of obesity-related complications [242, 243]
Studies report protective outcomes in liver and pancreatic injury, periodontal damage, soft tissue trauma, and even neurological impairments, including conditions involving altered serotonergic and dopaminergic signaling
In addition, 6-shogaol plays a role in modulating neuroinflammation by inhibiting the expression of proinflammatory cytokines in microglial cells (176)
Conflicts of interest The authors declare no conflict of interest
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