black box warning for glp 1 agonists GLP-1 Receptor and Carcinogenicity Risk: From Liraglutide to Oral Small Molecules The FDA sent a warning

The Ransel assay (RANDOX Laboratories, Crumlin, UK) was used to quantify the activity of glutathione peroxidase (GPX), which is an antioxidant enzyme that detoxifies cells from peroxides and organic hydroperoxides

As I say in the episode, its likely to be a top headline coming out of the ADA conference next week and might be the biggest news for diabetes this decade

This distinction matters clinically because it determines dosing, timing, and what results to expect at each stage of the protocol

Because this effect is entirely glucose-dependent, insulin secretion decreases as plasma glucose approaches normal levels, providing a significant safety advantage over traditional secretagogues

Engineered for sustained joint durability and performance