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Previous studies have shown that irisin treatment can inhibit the expression of pro-inflammatory cytokines, reduce macrophage migration, and induce a phenotypic switch in macrophages from an M1 to an M2 state (Madhu et al., 2022)

Reprod Biomed Online 31(4):544556

The change in the DNA causes the enzyme to be more thermolabile, which means that the enzyme loses its activity when exposed to moderate heat

They provide Certificates of Analysis for their products and state that purity exceeds 99% across their lineup

Tang W, Wu J, Jin S, He L, Lin Q, Luo F et al (2020) Glutamate and aspartate alleviate testicular/epididymal oxidative stress by supporting antioxidant enzymes and immune defense systems in boars