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the placebo also lost considerably more weight, with those who received the study medication losing an average of more than 13% of their body weight compared to a nearly 3% reduction in body weight for volunteers who received the placebo

Individual response to GLP-1 medication varies significantly based on starting weight, dosage, adherence, diet, and physiology

Moreover, modified leptin release from adipose tissue, characteristic of obesity, results in leptin resistance and diminished leptin sensitivity, further disrupting hypothalamic-pituitary regulation