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As soon as aflatoxin B1 enters the cells, they are metabolized by cytochrome P450, to aflatoxin-8, 9-epoxide which is highly reactive and unstable and requires the binding to a DNA or to the protein molecule in order to become more stable and it will form aflatoxin-N7-guanine that cause GC to TA transversion mutations which will directly affect the cell cycle by affecting the P53 gene which encodes for tumor suppressor protein that inhibits the development of cancer

doi: 10.1371/journal.pone.0179889 62 GanzT