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293 Furthermore, metabolic adaptations in CSCs, including a shift toward OXPHOS and FAO, enable them to sustain energy production even under low-nutrient conditions, increasing their resistance to glycolysis-targeting therapies

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Moreover, KO mice for liver IGF-1 gene developed muscle insulin resistance (it is important to mention that skeletal muscle myocytes express high number of IGF-1R), showing an increase in insulin concentrations and a substantial decrease in the insulin-induced autophosphorylation of the insulin receptor and IRS in skeletal muscle (being normal in liver and white adipose tissue)