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A major goal of vaccine and therapeutic development is to generate antibodies that prevent the entry of SARS-CoV-2 into cells by blocking either ACE2RBD binding interactions or S-mediated membrane fusion

So to put that into perspective: Beginning of Feb (immediately after injections) : Very red, itchy bumpy skin, small bumps turned into whiteheads or cystic acne

Physiological Reviews , 93 (4), 18031845

Immediate Effects: Pain relief: Some patients experience immediate pain relief within hours after the first injection due to the analgesic properties of vitamin B12

The recruitment status of the former is due to end in May 2021, while the latter is still recruiting and is scheduled to complete by January 2023