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Studies have shown that these enzymes are transcriptionally regulated by sex hormone receptorsestrogen receptor (ER) and androgen receptor (AR)which mediate ferroptosis surveillance independent of GPX4 and FSP1 (Liang et al., 2023)

Aguayo-Mazzucato, C

Ning D, Yang X, Wang T, Jiang Q, Yu J, Wang D

In the brain, these cells interact with antigen-presenting cells and release inflammatory cytokines such IL-17, IFN-, and TNF-, leading to neuroinflammation and dopaminergic neuron death [105]

The death of chondrocytes and the cartilage matrixs degradation can disrupt the cartilage-bone interfaces structure, consequently affecting osteoblasts and osteoclast activity (Miao et al., 2022)