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Anesthesiology 116 , 13471353 (2012)

A suboptimal intake of the essential amino acids increases the body's need for the non-essential amino acids either through diet or supplementation

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[166] reported that the mechanism of the pharmacologic inhibitory effects of SAMe on proinflammatory mediators, are, in part, mediated by altering the methylation capacity and blocking the binding of trimethylated H3K4 to the TNF- promoter through increasing MTA and SAH levels [166]

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