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Some patients report that semaglutide's appetite-suppressing effects make them less interested in eating breakfast, which can actually work in favor of levothyroxine absorption

However, it is important to note that, due to potential underreporting by the informants, there were also instances of unknown indications ( n = 2,281, 27.68%)

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Oestrogen dependence may be due to the upregulation of the 17-hydroxysteroid dehydrogenase-1 and aromatase genes, whereas progesterone resistance may result from the failure of progesterone receptor activation and transcription of progesterone target genes [99]