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for instance, strong mucoadhesion can inadvertently hinder the necessary mucus penetration required for deep epithelial access (an issue partially addressed by the adaptive systems discussed in Section 2.2.2.1)

Beyond MTHFR, polymorphisms in genes encoding drug transporters, such as SLC19A1 (rs1051266) and SLCO1B1 (SLCO1B15 and SLCO1B115), have been implicated in MTX transport efficiency and toxicity profiles

Convenience factors Oral administration wins decisively on convenience

KPV is thought to retain those same anti-inflammatory effects in a smaller, more stable form

The potential therapeutic effects of hydroxypropyl cellulose on acute murine colitis induced by DSS