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investigated infertile PCOS patients with obesity randomly assigned to metformin 1000 mg BID or to metformin 1000 mg BID combined with low-dose liraglutide 1.2 mg/day for 12 week, and demonstrated that weight, BMI, and WC decreased with both treatments, without significant difference between the two arms [59]
Microdosing starts at 0.125 mg (sometimes even lower) and increases in smaller increments
Intestinal barrier function non-alcoholic fatty liver disease interactions and possible role of gut microbiota
Both conditions frequently occur together in individuals with obesity, type 2 diabetes, insulin resistance, and unhealthy dietary patterns, which create a metabolic environment promoting both kidney stone formation and liver fat accumulation