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We extracted the culture medium after cell culture for ELISA detection, and we can see that the secretion of GLP-1 increases after adding berberine (Figure 7B)

2022;Jensen et al

By addressing weight loss, fat reduction, muscle preservation, and metabolic improvements, this combination could help individuals achieve better health outcomes than either treatment alone

To minimize side effects and maximize benefits, both medications require a gradual dose escalation

In clinical practice, based on clinical response or intolerance, the starting dose of medication is 10 mg/week, with increases of 5 mg every 24 weeks, up to a maximum dose of 2030 mg/week (Visser and van der Heijde 2009