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These channels affect gustatory processing by altering sensibility to changes in temperature (activated indirectly by tastants or directly by certain spices) in response to physical stimuli, such as mechanical forces and temperature, and by chemical agents (chemestesis), evoking sensations of touch, temperature, and pain, depending on the kind of subunit they are attached to

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The plot is from: sciencedirect.com/science/a

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However, in a model of type I diabetes, these mice displayed exacerbated hyperglycemia caused by the enhancement of the gluconeogenic pathway in the kidney (13)