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When FXR is inhibited, intestinal stem cells generate more L-cells, which produce GLP-1

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Meanwhile, the overall number of patients treated with GLP-1R agonists increased sharply, with the mean annual incidence of new prescriptions rising from 0.22% during 2011-2014 to 0.60% during 2015-2018, and then further to 2.11% in the 2019-23 period

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