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Researchers have developed peptides derived from histone sequences that, paradoxically, can induce immune tolerance to these same proteins

Hyperglucotoxicity and lipotoxicity Persistent hyperglycemia and excess fatty acids in the circulation due to overnutrition and IR have widespread and significant effects on cell function and mass

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TAAR1 & Activation of NET/DAT/SERT Reverse Transport: Nature's Homeostatic Safety Valve Under baseline physiological conditions, catecholamines (like dopamine and norepinephrine) are kept sequestered at extremely low levels in the presynaptic cytoplasm (representing only ~3% of the total terminal contents), with the vast majority safely packaged in acidic storage vesicles (Hussain et al., 2023)