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Liguori et al

Melanin pigmentation is a common feature of the oral mucosa

They are designed for individuals who are at a stable, healthy weight but struggle with localised pockets of stubborn fat, such as a double chin or love handles, that resist traditional diet and exercise

It is unclear from the Clinical Study Report whether patients were enrolled consecutively, creating a potential for selection bias (i.e., enrolment of patients who would most likely benefit from the treatment) that could overestimate the treatment effect

And any discussion about metabolism and growth, by definition has to include a discussion about growth hormones