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early changes in waist circumference Months 4-6: Continued steady weight loss

Administration of DSS in drinking water also resulted in the induction of a reproducible pro-inflammatory response, limited to the colon and characterized by lesions, loss of crypts, and infiltration of granulocytes, similar to PGN administration (Okayasu et al

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This is achieved through the slow gastric emptying process and the hormones effects on the brain regions that control appetite