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Molecular dynamics (MD) simulations, mass spectrometry and E194A site-directed mutagenesis revealed that PARP1-mediated ribosylation of PXR E194 enhanced CYP3A4 transcription, ultimately leading to excessive NAPQI production

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When someone is ill (such as diarrhea and vomiting), dehydrated due to excess physical activity or alcohol consumption, or has sustained serious injuries, they may require IV fluids

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