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Aberrantly activated glial cells exacerbate neuroinflammation and influence synaptic pruning processes, with complement C4-mediated synaptic phagocytosis playing a critical role

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FIGURE 21-7 Tenderness elicited by direct pressure between the ulnar styloid and triquetrum is consistent with an injury to the triangular fibrocartilage complex

27% switched to another medication (including older-generation obesity medications or switching between semaglutide and tirzepatide) 20% restarted their original medication 14% continued treatment through lifestyle modification visits with healthcare professionals such as dietitians or exercise specialists Less than 1% underwent metabolic and bariatric surgery Ongoing Obesity Care Remains Important According to the researchers, the findings highlight the value of continued, personalized support for people managing obesity, even after they stop a medication

Glucagon-like peptide-1 receptor agonists and risk for cardiovascular events in older adults treated with levothyroxine: a target trial emulation