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If it is affected, a person might feel sharp pain on the right side of the belly, have nausea, or notice yellowing of the skin (jaundice)
Continuation criteria require demonstrable benefit: typically 11 mmol/mol HbA1c reduction and 3% weight loss at 6 months for diabetes, or 5% weight loss at specified timepoints for obesity treatment
When you suddenly take in less fuel than your body is used to, it has to adapt
This strategy has been exploited in the long-acting GLP-1RA semaglutide (Novo Nordisk), for instance, which was approved for treatment of T2DM in 2017, and for treatment of obesity in 2021, and has since then become the most prescribed GLP-1RA 92