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Some people notice a metallic or off taste, foods they used to love losing their appeal, or Bruising and Injection Site Reactions on Semaglutide Bruising and mild injection site reactions, meaning redness, a small lump, itching, or tenderness, are common with subcutaneous semaglutide and are usually harmless

Additive cardiovascular effects haven't been studied

However, typical gastrointestinal side effects associated with GLP-1 agents remain

Contact your healthcare provider if heartburn persists beyond 1-2 weeks despite lifestyle changes and over-the-counter treatments, or if you experience red flag symptoms including difficulty swallowing, severe abdominal pain, persistent vomiting, or signs of gastrointestinal bleeding

Ensure you get enough lean protein to support muscle mass and metabolic needs