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Arch Pharmacol

What they could observe at a histological level was: Figure III

3.4 Osteoporosis Osteoporosis is typified by excessive bone resorption that arises via hyperactive osteoclasts, and is highly regulated by the RANKL/RANK signalling axisits activation initiates subsequent signalling of NF-B and MAPK to promote osteoclast differentiation and bone loss (Table 1, Row 19)