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However, the FDA has interpreted this study and put a warning on febuxostat that it should be used second line, after allopurinol

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HLA-Cw0602 associates with a twofold higher prevalence of positive streptococcal throat swab at the onset of psoriasis: a case control study

People with active cancers, untreated pituitary disorders, or certain metabolic conditions should avoid it unless specifically cleared by a medical provider (Mayo Clinic, 2024)

How the side effects compare Because both drugs act on the same hormone pathway, their side-effect profiles look broadly alike, and the problems are mostly digestive and tend to track the dose