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p.)r ep resen t- ing the positive control.After twohours,all groups received by gavage standard charcoalmeal (10%charcoal in 5% gum Arabic, 1mL/rat).Allratsweresacrificedafter30minutes,andthesmall intestine was carefully removed (pylorus region to cecum).The distance traveled by the charcoal and intestine length were both measured

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doi: 10.1016/j.cell.2010.02.027 12 LiauBBSieversCDonohueLKGillespieSMFlavahanWAMillerTEet al