Now, McDonald and collaborators are actively working to stand up a multisite clinical trial to assess whether GLP-1 medications can lower breast cancer incidence among women at high-risk, including those with a history of breast cancer
Carnitine metabolism in chronic liver disease
Patients with certain conditions, like severe gastrointestinal diseases or a history of pancreatitis, should avoid semaglutide
The mechanism is unclear, it may relate to subtle changes in blood glucose regulation or direct central nervous system effects during the initial absorption phase
Patients should focus on: Protein-rich foods at each meal (lean meats, fish, eggs, legumes, dairy) to support satiety and preserve lean muscle mass during weight loss High-fibre vegetables and whole grains to promote fullness and support digestive health Adequate hydration (1.52 litres daily for most people, though those with heart or kidney conditions should follow clinician advice on fluid intake) to distinguish thirst from hunger and support metabolic processes Mindful eating practices , including eating slowly, recognising fullness cues, and avoiding distractions during meals Limiting ultra-processed foods , which are typically energy-dense but nutrient-poor and may not trigger appropriate satiety signals Avoiding heavy alcohol consumption , particularly given the increased risk of pancreatitis with GLP-1 receptor agonists Physical activity plays a crucial role in weight management and metabolic health
