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Safety and Side Effects GLP-1 receptor agonists are generally safe, with predictable side effects: Gastrointestinal symptoms such as nausea, vomiting, and diarrhea are common but usually improve with gradual dose titration

Clinicians use the term informally to describe vaginal or vulvar changes noticed while taking a GLP-1 agonist

ATTAIN 1 clinical trial demonstrates that individuals with overweight and obesity who used the highest dose of orforglipron (36 mg) lost 12.4% of body weight after 72 weeks

Unlike synthetic hormones or stimulants, peptides work with your body's natural biology

And patients who are paying for their meds out of pocket are more likely to discontinue treatment after a short time