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In GLP-1-GIP-Lani, lanifibranor is delivered at roughly 7,000-fold lower systemic exposure via covalent conjugation to a peptide that targets it specifically into incretin-receptor-expressing cells, in principle escaping the dose-related side effects

This story was originally published by Men's Journal on Jan 20, 2026, where it first appeared in the News section

Forsythe CE, Phinney SD, Fernandez ML, Quann EE, Wood RJ, Bibus DM, et al

Draw the appropriate amount of bacteriostatic water into a sterile syringe

If you cannot access or afford newer GLP-1 medications, a generation of older weight loss drugs is still available