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The most significant published evidence to date comes from a phase 2 randomised controlled trial published in the New England Journal of Medicine in 2023, which evaluated retatrutide across multiple doses in adults with obesity

Participants in a recent two-year study each lost an average of 35 pounds, or almost 15% of their total body weight

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Obese individuals may require doses at the higher end of the range, though this should be done under medical supervision

The number on the price tag is rarely the most important number