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However, the use of conventional anticancer agents has been highly limited due to the random tissue-distribution of cytotoxic anticancer drugs following systemic administration, which can cause non-specific toxicity to the normal tissues

Cecal levels of Erysipelatoclostridium abundance have been positively correlated with dyslipidemia 93 , and a report that WD decreased the relative abundance of Erysipelatoclostridium and that the abundance of Erysipelatoclostridium negatively correlated with obesity-related indices 90 may partially explain our observation that decreased levels of Erysipelatoclostridium were present in the 5A-1MQ-treated group and the WD control group relative to the vehicle-treated group switched from WD to LD

Br J Clin Pharmacol 56:635638