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Acknowledgements This work was supported in part by National Natural Science Foundation of China (81903018), Natural Science Foundation of Sichuan (2022NSFSC1333 and 2023YFS0178), Natural Science Foundation of Chengdu Medical College (CYZZD21-01), the High-level Talents Research Foundation of the First Affiliated Hospital of Chengdu Medical College (CYFY-GQ37), CMC Excellent-talent program (2024qnGzn01), Key Clinical Specialty Construction Project of Sichuan Province (2024GXWKP002)