Han, Y., et al
Up to now, powerful genetic tools allowed clarification of the significance, dispensability and potential of cystine transporters for ferroptotic cell death in PDAC and breast cancer ( via xCT ( A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport ( in vitro studies as efficient inducer of ferroptosis in many different cancer types, including breast, PDAC, lymphoma, renal, brain and ovarian cancers (50, 51) and sorafenib (52)
Determination of adenosine triphosphate in kidney tissue Adenosine triphosphate in renal samples was determined based on the method previously described by Botker et al., [40] utilizing an HPLC system (Jasco Corporation, Ishikawa-Cho, Hachioji, Tokyo, Japan)
Discovery of Dotinurad (FYU-981), a new phenol derivative with highly potent uric acid lowering activity
But reduced appetite does not automatically translate to optimal nutrition
