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In SH3 and multiple ankyrin repeat domains 3 (Shank3) KO mice, a widely used mouse model with autistic-like social deficit and repetitive behavior, reduced cortical actin filaments and Rac1/PAK activity were observed, which were rescued by reactivating Rac1 or inhibiting cofilin activity ( Fragile X Syndrome Many Rho signaling proteins were reported to be linked to intellectual disability (Newey et al., 2005

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