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We have identified two candidates (hexokinase 2 and choline kinase), as potential metabolic targets

This study was conducted in Japan, South Korea, Taiwan and the Philippines, where patients with type 2 diabetes have a number of distinct features, including a relatively low body mass index (BMI) (in this study a mean of 25.3 kg/m 2 ) and tend to have reduced cell function compared with Western subjects

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In STEP-1 (N=1,961), FDA-approved semaglutide 2.4 mg produced 14.9% mean body weight loss at 68 weeks compared to 2.4% with placebo [13]