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A clinical review noted that orally administered glutathione "cannot be relied upon for therapeutic purposes," which is why researchers and clinicians have used precursor strategies (NAC, GlyNAC) or IV delivery to achieve meaningful systemic increases
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Oral Activity of the Growth Hormone Releasing Peptides
(5) These increases were associated with a marked decrease in oxidative stress and improvements in immune function, as indicated by a better oxidized (GSSG) to reduced (GSH) glutathione ratio and increased natural killer cell activity
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