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89 Although the majority of studies suggest that an increase in NAD+ drives cellular proliferation, prior investigations have proposed that a decrease in NAD+ levels can lead to genomic instability, subsequently instigating liver tumorigenesis

10.1371/journal.pone.0143660 18 FrugierT.TaylorJ

This has led many functional medicine practitioners to seek alternative delivery methods that can bypass the destructive environment of the stomach and deliver the intact molecule directly to the cells that desperately need it

Your body is quite good at regulating B12 levels and eliminating excess through your kidneys

However, Li et al reported that insulin-mediated up-regulation of GSH synthesis in cardiac myocytes required PI3K, MEK and p38 MAPK (Li et al., 2003)