Overall, for treatment of hyperglycaemia, metformin remains the agent of choice in most people with diabetes, based on its glucose-lowering efficacy, minimal risk of hypoglycaemia, lack of weight increase and affordability
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These improvements may prove critical for women with PCOS should GLP-1 medications obtain the appropriate authorisation, as managing weight and insulin resistance can significantly improve overall health and fertility
Brown noted that, without this new evidence, some women taking GLP-1s might consider terminating otherwise wanted pregnancies out of safety concerns
however, additional research is required to determine the strategies that will result in economically producible levels of these inhibitors