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This may help explain why it is little used by health professionals

10.1023/a:1018893220943 113 SikiricP.PetekM.RucmanR.SeiwerthS.GrabarevicZ.RotkvicI.et al (1993)

These include the following: IgG4-Related Variant, Juvenile Variant, Fibrous Variant, Hashitoxicosis Variant, and Painless (or silent) Thyroiditis

At present, regulatory agencies like the FDA and the European Commission evaluate CQDs on a case-by-case basis, irrespective of a specific regulatory procedure as these nanomaterials do not fit neatly within existing classifications for pharmaceuticals, biologics, or medical devices [172]