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107 In another randomized controlled trial in overweight adults with evidence of vascular dysfunction, 450 mg per day of a hesperidin supplement for six weeks resulted in lower blood pressure and a decrease in markers of vascular inflammation

An alternative approach escalates both agents simultaneously but at slower intervals, extending the total escalation period to twenty weeks or longer

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This has contributed to the interest in nontranscriptional effects of ER in the nervous system and may be a particularly useful strategy when dealing with cells that can project to sites at considerable distance