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Based on published data: Tirzepatide: Highest average HbA1c reduction in trials Semaglutide: Strong glucose control + proven cardiovascular benefit Dulaglutide & Liraglutide: Reliable, well-studied options Oral semaglutide: Effective non-injectable alternative But 'best' depends on: Baseline HbA1c, Cardiovascular risk, Weight goals, Tolerability, Convenience, and Physician guidance

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