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A 2025 randomized, double-blind, placebo-controlled trial published in Clinical Nutrition found that 15 mg/day of hydroxytyrosol improved antioxidant and anti-inflammatory status in overweight individuals with prediabetes over 16 weeks, while preserving insulin sensitivity (Moratilla-Rivera et al., 2025)

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"If newly identified safety signals are identified, the FDA will determine what, if any, actions are appropriate after a thorough review of available data." These actions may include requiring labeling changes or development of a Risk Evaluation and Mitigation Strategy, a program that helps ensure a medication's benefits outweigh its risks

Individuals with irregular schedules, cognitive impairment, or difficulty adhering to medication routines may not be ideal candidates

Efficacy and safety of luteinizing hormone-releasing hormone antagonist cetrorelix in the treatment of symptomatic benign prostatic hyperplasia