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There is a significant increase in the incidence of allergic and autoimmune diseases, such as asthma, atopic dermatitis, allergic rhinitis, chronic sinusitis, food allergies, celiac disease and inflammatory bowel disease

A responsible medical discussion should include possible benefits, limitations, risks, alternatives, red flags, and a plan for monitoring progress

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Due to the complex interaction of different factors that contribute to an effective immune response, there may be more than one correlate of protection, and the mechanisms of protection during natural infection may differ from those seen after vaccination

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