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Diabetes Care 32(5):762768 Buse JB, Henry RR, Han J, Kim DD, Fineman MS, Baron AD et al (2004) Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes

Dysbiosis of the gut microbiota disrupts the structure and function of the intestinal epithelial barrier [128], forming harmful metabolic profiles [129], which induce inflammation and immune dysfunction via the gut-kidney axis [130, 131], exacerbating renal injury [132]

Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus

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These drugs are manufactured peptides, taken weekly, that fundamentally alter the brains appetite regulation and the guts nutrient handling